In Romania, modafinil is assessed as a stimulant doping agent and it is prohibited in sports competitions.

It ought to be utilised with warning in people with uncontrolled hypertension, unstable angina, or current myocardial infarction.

acetazolamide will boost the stage or effect of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.

ribociclib will enhance the amount or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

modafinil will minimize the level or outcome of fruquintinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. If coadministration with reasonable CYP3A4 inducers is unavoidable, go on to administer fruquintinib at advised dosage.

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 As everyone’s favorite Modafinil lab rat, I made a decision to take a look at out two prevalent microdosing protocols to the check it out here earlier pair months and in this article’s what I found:

Dose changes of those medicines and other medicines which are substrates for CYP2C19 may very well be important if modafinil is coadministered

stiripentol will improve the amount or outcome of modafinil by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep track of Carefully. Think about lessening the dose of CYP2C19 substrates, if adverse reactions are knowledgeable when administered concomitantly with stiripentol.

modafinil will improve the amount or influence of rabeprazole by influencing hepatic enzyme CYP2C19 metabolism. Slight/Significance Unknown. Net impact on pantoprazole steps mysterious on account of opposing results of CYP450 enzymes; check

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rifapentine will lessen the extent or outcome of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.

Blood levels of cyclosporine can be decreased when utilised with PROVIGIL. Checking of circulating cyclosporine concentrations and proper dosage adjustment for cyclosporine really should be considered when utilised concomitantly with PROVIGIL.

In 2008, Cephalon compensated $425m and pleaded responsible to your federal felony charge associated with its promotion of off-label takes advantage of for Provigil and two other drugs. ^